Effective COVID-19 Treatment Guidelines

by Heidi N du Preez

These guidelines are based on extensive research, which is explained in this video and a more in-depth scientific peer-reviewed publication (unpublished to date). Latest evidence indicates that COVID-19 appears to be a disease associated with epithelial and endothelial dysfunction and disruption of barrier functions, which may underlie the various symptoms experienced, and can result in development of ARDS, proteinuria, acute kidney injury and multiple organ failure1-9. These guidelines outlined below are aimed at restoring the epithelial and endothelial layer and thereby preventing viral entry into the cell, modulating inflammation, preventing epithelial and endothelial permeability and consequent oedema, coagulation and organ dysfunction.  

Your health is your right, insist on the right treatment! COVID-19 is treatable by simple measures.

Prevention

#MSM (methylsulfonylmethane) or MSM combo – 1 to 2 heaped tsp daily mixed into water (2g MSM daily)

and/or *NAC (N-acetylcysteine) 600mg - 1x capsule twice daily

MSM has a blood thinning effect, therefore monitor blood viscosity if on blood thinners
*ACC 200 contains only very low dose NAC, which is not high enough to effectively combat infection

Optional: Multi Immune or alternatively Selenozinc 50mg (selenium and zinc) 1x daily or Zinplex, Vitamin C 1000mg daily, Vitamin D3 5 000 IU daily

Various marine sulfated polysaccharides, such as fucoidan and carrageenan, are promising inhibitors of SARS-CoV-2 infection3,10,11.

Dietary guidelines:

  • Cut down on alcohol and caffeine intake, as well as smoking
  • Include at least 5 to 7 servings of vegetables daily in the diet, especially cruciferous veggies (broccoli, brussels sprouts, cabbage, cauliflower)
  • Each meal should contain a good source protein, with animal protein at least once daily
  • Drink 300ml purified water per 10kg body weight daily

Treatment

Mild to moderate symptoms:

#MSM or MSM combo – 1 heaped scoops two to three times daily mixed into water (3 – 4g MSM daily)

*NAC 600mg - 2x capsule twice daily

Ozonide Herbal (antiviral properties) – 6x drops twice daily (in water or best to place the drops into empty capsules to mask the taste)

MSM has a blood thinning effect, therefore monitor blood viscosity if on blood thinners
*ACC 200 contains only very low dose NAC, which is not high enough to effectively combat infection

Optional: Multi Immune or Selenozinc 50mg (selenium and zinc) 1x daily or Zinplex, Vitamin C 1000mg daily, Vitamin D 5 000 IU daily

Various marine sulfated polysaccharides, such as fucoidan and carrageenan, are promising inhibitors of SARS-CoV-2 infection3,10,11.

Dietary guidelines:

  • Avoid alcohol and caffeine12-14 and ideally quit smoking15-17.
  • Include at least 5 to 7 servings of vegetables daily in the diet, including cruciferous veggies (broccoli, brussels sprouts, cabbage, cauliflower)
  • Each meal should contain a good source of protein, with animal protein at least once daily
  • Drink 300ml purified water per 10kg body weight daily
  • Whey protein: 2 to 3 heaped tablespoons daily mixed into water, smoothies or food. Whey protein is high in cysteine and albumin. 

Moderate to severe symptoms:

IV NAC upon hospital admission - (40mg/kg/day) for 3 to 5 days18

Doxycycline 100mg qd 5 to 7 days (as protease inhibitor, attenuating shedding of the endothelial glycocalyx19-22)

Optional: Antiviral medication

Considerations:

  • Steroids, aspirin, acetaminophen and NSAIDs might enhance viral replication, as well as aggravate epithelial and endothelial dysfunction and the cytokine storm23,24, and should therefore not be given without a sulfur-donor such as IV NAC.
  • Whey protein, high and cysteine and albumin, should be added to the diet25,26.
  • High dosages of vitamin C causes hyperoxaluria through endogenous conversion of ascorbic acid to oxalate27. Both vitamin C28 and oxalates29 require conjugation through sulfation and will contribute to epithelial and endothelial dysfunction. Best to give vitamin C together with IV NAC as sulfur donor.
  • Ventilation (VT) – avoid high tidal volume2,21,30,31. However, low VT may not be the best approach for all patients with ARDS, since hypercapnia was common in patients with COVID-19–associated ARDS while using low tidal volume VT, which resulted in increased pulmonary dead space. Intermediate VT was used to correct hypercapnia efficiently in these patients, while not excessively increasing driving pressure32. High-flow nasal oxygen the best option.
  • Avoid both hypervolemia and hypernatremia, which are injurious to the endothelial barrier function2,33,37. Albumin is effective for volume repletion.

Severe to critically ill:

IV NAC or IV sodium thiosulfate (STS). STS might be a better option to modulate the cytokine storm in the critically ill.

Doxycycline 100mg bid 5 to 7 days (as protease inhibitor, attenuating shedding of the endothelial glycocalyx19-22)

Sodium thiosulfate dosage:

Adults: 50 mL (12.5 g) of sodium thiosulfate (rate of 5 mL/minute), initially daily and when symptoms subside, every 2nd or 3rd day

Paediatric 0 – 18 years: 1 mL/kg of body weight (250 mg/kg or approximately 30-40 mL/m2 of BSA) (rate of 2.5 to 5 mL/minute) not to exceed 50 mL total dose of sodium thiosulfate. Give initially daily and when symptoms subside, every 2nd or 3rd day

NAC dosage:

IV NAC at a loading dose of 150 mg/kg on the first day, followed by a dose of 50 mg/kg/day for 3 to 5 days18

Optional: Antiviral medication

Considerations:

  • Steroids, aspirin, acetaminophen and NSAIDs might enhance viral replication, as well as aggravate epithelial and endothelial dysfunction and the cytokine storm23,24, and should therefore not be given without a sulfur-donor such as IV NAC.
  • Enteral feeding – add L-cysteine to the feed
  • Add albumin20,33-35 or fresh frozen plasma6,36 to restore the endothelial layer. Moreover, albumin has immunomodulatory and anti-inflammatory6, antioxidant, anticoagulant and antiplatelet-aggregational properties35
  • Avoid both hypervolemia and hypernatremia, which are injurious to the endothelial barrier function2,33,37. Albumin is effective for volume repletion.
  • Etanercept has been proposed for use in COVID-19 to reduce mortality of toxic epidermal necrolysis (TEN)38
  • Check for glucose-6-phosphate dehydrogenase (G6PD) deficiency before hydroxychloroquine is administered and if present, give IV NAC to avoid risk of hemolysis in G6PD-deficient patients39,40
  • Limit the use of antibiotics, unless there is a known secondary infection.

Important notes in general:

  • Ivermectin is contraindicated when blood-brain-barrier (BBB) is compromised, however, SARS-CoV-2 activation of cytokines such as IL-1, IL-16, and TNFα causes injury to the BBB41,42.
  • NAC is not only a precursor to glutathione, but also to hydrogen sulfide, inorganic sulfate, taurine and support albumin synthesis35.
  • Hydrogen sulfide (H2S) - stress and hypoxic states would favour sulfide as an ‘emergency’ substrate that balances and complements the electron-donating effect of Krebs cycle-derived electron donors, and/or play cellular roles in specialized situations43. Exogenous H2S, released from natural sulfur compounds and sulfur amino acids such as NAC, have shown protective effects in biological systems44.
  • NAC, MSM and sodium thiosulfate have low toxicity in human studies and as such, is regarded as GRAS (generally recognized as safe) by the FDA44,45,46 and can be used as an ‘off label’ drug.
  • Various research studies indicated that NAC can modulate the immune system, suppress viral replication, and reduce inflammation17,18,39, apart from its antioxidant properties47,48.
  • It has been demonstrated that NAC suppresses NF-κB activation, a factor that stimulates the transcription of many cytokines participating in the inflammatory-repair reaction. NAC therefore plays a role in regulating inflammation and tissue repair49.
  • It has also been found that sodium thiosulfate (STS) inhibited LPS-induced production of cytokines, lung permeability, histological lung injury, and NF-κB activation in the lung. STS also prevented upregulation of IL-6 in the mouse lung50.
  • COVID-19 is a result of a defective innate immune response, thus first line of defence, more so than adaptive immunity.

References:

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  50. du Preez HN. Why anti-inflammatory drugs are contraindicated in COVID-19. Published online 10 April 2020. https://www.myhealingprotocol.com/blogs/chronic-disease/why-anti-inflammatory-drugs-are-contraindicated-in-covid-19-revised

Heidi N du Preez, M.Sc., Pr.Sci.Nat.

Heidi N. du Preez is an independent medical researcher in private practice. She holds a Master degree in Science and is registered as a Professional Natural Scientist.

Email: heididp@myhealingprotocol.com

Comments

5 comments

Heidi du Preez

Pieter Erasmus – the supplements mentioned are either available from the online shop from myHealing, as well as selected health shops and chemists.

Riane Venter – if you want to prevent COVID-19, you only need to follow the guidelines stipulated under ‘prevention’ and get either MSM or NAC from a health shop to take as supplement.

Eduard Lotz

👌🏽👌🏽

Riane Venter.

I do not understand any of the medical terms, thus cant go buy the right medicine

Mackie

Thank you for valuable information.

Pieter Erasmus

Are all the stuff available from a chemist ?

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